Publication: Mutations in Noncoding Cis-Regulatory Elements Reveal Cancer Driver Cistromes in Luminal Breast Cancer
El Ghamrasni S, Quevedo R, Hawley J, Mazrooei P, Hanna Y, Cirlan I, Zhu H, Bruce JP, Oldfield LE, Yang SYC, Guilhamon P, Reimand J, Cescon DW, Done SJ, Lupien M, Pugh TJ. Mol Cancer Res October 18 2021 DOI: 10.1158/1541-7786. MCR-21-0471
Publication: Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity
SYC Yang, Lien SC, Wang B, Clouthier DL, Hanna Y, Cirlan I, Zhu K, Bruce JP, El Ghamrasni S, Iafolla MAJ, Oliva M, Hansen AR, Spreafico A, Bedard PL, Lheureux S, Razak ARA, Speers V, Hal K Berman HK, Haibe-Kains B, Brooks DG, McGaha T, Butler M, Bratman SV, Ohashi PS, Siu LL+, Pugh TJ+.
Nat Commun. 2021 Aug 26;12(1):5137. doi: 10.1038/s41467-021-25432-7. PMID: 34446728 (SRA)
Publication: Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape
Nat Commun. 2021 Jul 7;12(1):4193. doi: 10.1038/s41467-021-24348-6. PMID: 34234122. (SRA)
Till and McCulloch Paper of the Year Award (Translational)
“Personalized circulating tumor DNA analysis as a predictive biomarker in solid tumor patients treated with pembrolizumab” Bratman S & Pugh T. Nature Cancer (2020). 1, 873-881
Awarded by Princess Margaret Cancer Centre to mark the 50th anniversary of the publication of Drs. Ernest McCulloch and James Till’s seminal stem cell paper. (CA)
Publication: Maximizing cancer prevention through genetic navigation for Lynch syndrome detection in women with newly diagnosed endometrial and nonserous/nonmucinous epithelial ovarian cancer
Kim SR, Tone A, Kim RH, Cesari M, Clarke BA, Eiriksson L, Hart TL, Aronson M, Holter S, Lytwyn A, Maganti M, Oldfield L, Gallinger S, Bernardini MQ, Oza AM, Djordjevic B, Lerner-Ellis J, Van de Laar E, Vicus D, Pugh TJ, Pollett A, Ferguson SE.
Cancer. 2021 May 13;. doi: 10.1002/cncr.33625. PMID: 33983630. (CA)
Publication: Understanding the clinical implication of mismatch repair deficiency in endometrioid endometrial cancer through a prospective study.
Kim SR, Tone A, Kim RH, Cesari M, Clarke BA, Eiriksson L, Hart T, Aronson M, Holter S, Lytwyn A, Lajkosz K, Oldfield L, Gallinger S, Bernardini MQ, Oza AM, Djordjevic B, Lerner-Ellis J, Van de Laar E, Vicus D, Pugh T, Pollett A, Ferguson SE.
Gynecol Oncol. 2021 Apr;161(1):221-227. doi: 10.1016/j.ygyno.2021.01.002. PMID: 33478752.
Canadian Institutes of Health Research Grant
Understanding inevitable relapse of multiple myeloma following highly effective anti-BCMA treatment
Publication: Gradient of developmental and injury-response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity
Richards LM*, Whitley OKN*, MacLeod G, Cavalli FMG, Coutinho FJ, Jaramillo JE, Svergun N, Riverin M, Croucher DC, Kushida M, Yu K, Guilhamon P, Rastegar N, Ahmadi M, Bhatti JK, Bozek DA, Li N, Lee L, Che C, Luis E, Park NI, Xu Z, Ketela T, Moore RA, Marra MA, Spears J, Cusimano MD, Das S, Bernstein M, Haibe-Kains B, Lupien M, Luchman HA, Weiss S, Angers S, Dirks PB+, Bader GD+, Pugh TJ+.
Nature Cancer. 2021 Feb. (SRA)
Publication: An integrative DNA sequencing and methylation panel to assess mismatch repair deficiency
Oldfield LE, Li TT, Tone A, Aronson M, Dowar M, Edwards M, Holter S, Quevedo R, Van de Laar E, Lerner-Ellis J, Pollett A, Clarke B, Tabori U, Gallinger S, Ferguson S, Pugh TJ
JMD. 2021 Feb;23(2):242-252. doi: 10.1016/j.jmoldx.2020.11.006. PMID: 33259954 (SRA)
Neuroendocrine Tumour Research Foundation – Pilot Project Award Grant
Establishment and genome characterization of PNET mouse models
Roche/Genentech imCORE IDEA program Grant
Screening and monitoring of cancer and immune systems from BRCA-mutant tumours treated with atezolizumab (Heartbeat OV)
TD Ready Challenge Grant
Early detection of cancer in Hereditary Breast and Ovarian Cancer patients and Lynch syndrome patients using cell-free DNA
Publication: Tumor site discordance in mismatch repair deficiency in synchronous endometrial and ovarian cancers.
Kim SR, Tone A, Kim R, Cesari M, Clarke B, Eiriksson L, Hart T, Aronson M, Holter S, Lytwyn A, Maganti M, Oldfield L, Gallinger S, Bernardini MQ, Oza AM, Djordjevic B, Lerner-Ellis J, Van de Laar E, Vicus D, Pugh TJ, Pollett A, Ferguson SE.
Int J Gynecol Cancer. 2020 Dec;30(12):1951-1958. doi: 10.1136/ijgc-2020-001927. PMID: 33082239
Canada’s Top 40 Under 40
Caldwell Partners (Leadership Award, Specialty: Scientific research)
Celebrates the achievements of 40 Canadians in the private, public and not-for-profit sectors, who have demonstrated remarkable success before passing the age of 40.
Honourees are chosen based on five major criteria: Vision and leadership, Innovation and achievement, Impact, Community involvement and contribution, Growth and development strategies.
Publication: Assessment of Genetic Drift in Large Pharmacogenomic Studies
Quevedo R, Smirnov P, Tkachuk D, Ho C, El-Hachem N, Safikhani Z, Pugh TJ+, Haibe-Kains B+ Cell Systems. 2020 Sep 4;S2405-4712(20)30323-9. PMID: 32937114 (SRA)
Canadian Foundation for Innovation – John R. Evans Leaders Fund Grant
Defining cancer and immune landscapes in multiple myeloma using single cell transcriptomics and ultradeep DNA sequencing.
Ontario Graduate Scholarship
Brain cancer genomics, Graduate student.
Awardee Name: Laura Richards. Ontario Ministry of Training of Colleges and Universities. Toronto, ON, Canada.
Merit-based scholarship awarded to Ontario’s best graduate students in all disciplines of academic study.
Total Amount: $15,000 CAD
Ontario Graduate Scholarship
Awardee Name: Rachel Soyoun Kim
Merit-based scholarship awarded to Ontario’s best graduate students in all disciplines of academic study.
Total Amount: $15,000 CAD
Publication: Performance characteristics of screening strategies to identify Lynch syndrome in women with ovarian cancer
Kim SR, Tone A, Kim RH, Cesari M, Clarke BA, Eiriksson L, Hart T, Aronson M, Holter S, Lytwyn A, Maganti M, Oldfield L, Gallinger S, Bernardini MQ, Oza AM, Djordjevic B, Lerner Ellis J, Van de Laar E, Vicus D, Pugh TJ, Pollet A, Ferguson SE.
Cancer. 2020 Aug 18. PMID: 32809219 (CA)
Publication: Personalized circulating tumor DNA analysis as a predictive biomarker in solid tumor patients treated with pembrolizumab
Bratman SV*, Yang SYC*, Iafolla MAJ, Liu Z, Hansen AR, Bedard PL, Lheureux S, Spreafico A, Razak AA, Shchegrova S, Louie M, Billings P, Zimmermann B, Sethi H, Aleshin A, Torti D, Marsh K, Eagles J, Cirlan I, Hanna Y, Clouthier DL, Lien SC, Ohashi PS, Xu W, Siu LL+, Pugh TJ+
Nature Cancer. 2020 Aug 3 1:873–881 (SRA)
Publication – CReSCENT: CanceR Single Cell ExpressioN Toolkit
Mohanraj S*, Díaz-Mejía JJ*, Pham MD, Elrick H, Husić M, Rashid S, Luo P, Bal P, Lu K, Patel S, Mahalanabis A, Naidas A, Christensen E, Croucher D, Richards LM, Shooshtari P, Brudno M+, Ramani AK+, Pugh TJ+.
Nucleic Acids Res. 2020 Jul 2; 48(W1):W372-W379. doi: 10.1093/nar/gkaa437. PMID: 32479601 (CA)
Perlman Family CCARE Lynch Syndrome Research Prize
Oncology, Clinical fellow. Awardee Name: Rachel Soyoun Kim.
The FWC Research Grants and Awards program strives to accelerate the research of young investigators and promote the long-term success of the gynecologic oncology field.
Total Amount: $20,000 USD
Publication: Centromeric cohesion failure invokes a conserved choreography of chromosomal mis-segregations in pancreatic neuroendocrine tumor
Quevedo R*, Spreafico A*, Bruce J, Danesh A, El Ghamrasni S, Giesler A, Hanna Y, Have C, Li T, Yang SYC, Zhang T, Asa SL, Haibe-Kains B, Krzyzanowska M, Smith AC, Singh S, Siu LL+, Pugh TJ+.
Genome Medicine. 2020 April 28;12(18):1-15. PMID: 32345369 (SRA)
CIHR Women’s Health Clinical Mentorship Award
Endometrial Cancer, Clinical fellow. Awardee Name: Rachel Soyoun Kim.
The aim is for trainees, students or residents to be paired with and mentored by a women’s health clinician-specialist on a one-year research project with the goal of improving clinical care.
Total Amount: $50,000 CAD
Alex’s Lemonade Stand Foundation – Single-cell Pediatric Cancer Atlas Grant
Dissecting pediatric brain tumour progression using single-nuclei sequencing
Highly Cited Researchers List, Clarivate Web of Science
Recognition of a body of published work over the last decade that has ranked in the top 1% by citations for field and year in Web of Science (~6100 researchers recognized internationally).
http://recognition.webofsciencegroup.com/awards/highly-cited/2019/
CIHR Doctoral Award
Graduate Student. Awardee Name: Petr Smirnov. Canadian Institutes for Health Research. Toronto, ON, Canada.
The aim is to promote continued excellence in Canadian research by rewarding and retaining high-calibre doctoral students at Canadian institutions. By providing support for a high-quality research training experience to awardees, the CGS D program strives to foster impacts within and beyond the research environment.
Total Amount: $105,000 CAD
Publication: High efficiency error suppression for accurate detection of low-frequency variants
Wang TT, Abelson S, Zou J, Li T, Zhao Z, Dick JE, Shlush LI, Pugh TJ+, Bratman SV+
Nucleic acids research, 2019 May 25;gkz474 (SRA)
Publication: Evaluation of methods to assign cell type labels to cell clusters from single-cell RNA-sequencing data
Diaz-Mejia JJ, Meng EC, Pico AR, MacParland SA, Ketela T, Pugh TJ, Bader GD, Morris JH.
F1000Res. 2019 Mar 15; 8. pii: ISCB Comm J-296. PMID: 31508207 (CA)
Princess Margaret Innovation Accelerator Fund Grant
CapTCR-seq: Immune repertoire sequencing for cancer diagnosis & immunotherapy response